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tdh [2019-08-01 11:22:26]
L-threonine dehydrogenase
function
threonine utilization
product
L-threonine dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.8|Utilization of threonine/ glycine]Gene
Coordinates
1,770,461 1,771,504
The protein
Catalyzed reaction/ biological activity
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH (according to Swiss-Prot)Protein family
[SW|zinc-containing alcohol dehydrogenase family] (according to UniProt)[SW|Cofactors]
NAD+ (according to UniProt)Structure
[PDB|2DQ4] (from ''Thermus thermophilus'', 47% identity, 63% similarity)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]-[gene|1BC05699DEB3A16944FB8305F22976AED75805E8|kbl]
description
[Pubmed|22383849]
view in new tabBiological materials
Mutant
BKE16990 ([gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE16990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACAATCCTCCTTGAA, downstream forward: _UP4_TTAATTCCATAAAGGGGGATBKK16990 ([gene|8E64B62F15B92A2AACD68B913909100AE276D114|tdh]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK16990 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTACAATCCTCCTTGAA, downstream forward: _UP4_TTAATTCCATAAAGGGGGAT